Targeting:
The formal Biosignature and Vector Development Core, a new addition to the labs, is a
collaborative effort among several types of systems with commercial input. A phage
display facility has been established for mining peptide targets and is operated by Dr.
Boles. Recombinant mAb production will be managed by Tom Diacovo, MD, PhD, an expert in
this area and a collaborator on other projects. Finally, the application of genomic
analysis of banked cancer or other tissue specimens and bioinformatic approaches will
suggest likely new targets and is be managed by Dr. Rakesh Nagarajan. These elements
will be supplemented by numerous commercial sources of small molecules available to us
through many research contracts.
In addition, the Center For Computational Biology is a collaborator in C-TRAIN for modeling
and algorithm development.