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Skip Navigation LinksCore Functions : Chemistry


The scope of the chemistry facilities extends from formulation, vialing, and sterilization of emulsion-based contrast agents, to synthesis of novel compounds (metal chelators, active imaging compounds such as radionuclide ligands and CT agents), to full analytical and dosimetry capabilities with HPLC, GC, TLC, Mass Spectrometry, NMR, etc. Available are: 1) Two Microfluidics M-110S microfluidizers with post-interaction chamber pressure monitoring for emulsion production, 2) a Malvern Zetasizer 4 laser light scattering particle sizer for submicron particle sizing. 3) a Coulter Multisizer II for micron range particle counting and sizing; 4) a Labconco console tray/bottle lyophilizer for producing and storing antibody generated by large scale hybridoma production and purification; 5) a custom-designed Sterile King autoclave with roller bottle, misting and external pressurization; 6) Olympus phase microscope for visual emulsion evaluation; 7) Brookfield viscometer and osmometer; 8) Laminar flow biohood for preparation: 9) a Bruker mq20 Minispec Analyzer for characterization of gadolinium bearing agents and fluorine determination; 10) Agilent 6890 plus gas-liquid chromatograph and autosampler with flame ionization and thermal conductivity detectors for measuring perfluorocarbon concentrations in the emulsion, blood and tissues; 11) Waters HPLC 600S controller, 717 autosampler, 474 scanning fluorescence detector, 2487 dual wavelength detector, 626 pump and Compaq computer with integration software, and an Alltech HPLC evaporative light scattering detector (ELSD); and 12) a136XT Peptide synthesizer (CS Bio Co.; Menlo Park, CA)

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