C-TRAIN Overview:

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Our Mission |
Facilities |
Major Resources |
Core Functions

The premise and motivation for establishing the Consortium for Translational Research in Advanced Imaging and Nanomedicine (C-TRAIN) is to facilitate interdisciplinary, collaborative basic and clinical research in imaged-based diagnostics and novel biocompatible nanotechnologies for targeted delivery of genes and drugs. We seek to create a showcase of talent, training, resources, and facilities that will attract both traditional academic support as well as corporate investment consonant with the academic mission of the university to develop and deploy new knowledge and technology related to the improvement of human health related principally to cardiovascular disease and cancer, but extending to other conditions that involve inflammatory and proliferative elements. Accordingly C-TRAIN will pursue:

  • in vivo characterization of the cellular and molecular mechanisms of disease in individual patients (“personalized medicine”)
  • targeted delivery of therapeutic agents
  • longitudinal evaluation of targeted therapies
  • clinical trials of nanobiomarkers as surrogate measures of drug efficacy

C-TRAIN operates under aegis of Department of Medicine but with direct affiliations with other Departments such as Biomedical Engineering, Physics, Division of Biology and Biomedical Science, among many others. C-TRAIN is expected to serve as a model for establishment of cross-talk between Medical School and Danforth campuses for translational research in nanotechnology related to biology. Academic affiliation is anticipated to include all researchers and clinicians engaged in nanomedicine, especially in vivo applications, and to other scientists and commercial collaborators seeking avenues for development of nanosystems or nanotechnologies (sensors, sorters, microscopy, etc.) with potential to improve human health whether in vivo or in vitro. C-TRAIN will provide a venue for faculty networking in areas of imaging and applied nanotechnologies to:

  • support multidisciplinary grant proposals with thematic appeal to the new funding initiatives that involve “team science”
  • facilitate collaborative research efforts among diverse faculty groups, in an environment primed for translation of academic ideas to the next phases of development and clinical testing
  • establish focused intellectual property expertise and consult in areas of licensing, contracts, and assessment of commercial potential for new ideas
  • provide direct avenues for technology transfer
  • operate shared resources and services for qualified and interested researchers and collaborators
  • develop student training programs and the training grants that support them, including exposure to principles of entrepreneurship
  • pursue joint collaborative research arrangements with industry scientists working as team members that will garner multivendor corporate financial support for research
  • enhance appeal of academic research to local and national venture capital groups

Copyright C-TRAIN 2007-2011