BIOGRAPHICAL SKETCH Provide the following information for the key
personnel in the order listed for Form Page 2. Follow the sample format for each person. DO NOT EXCEED FOUR PAGES. |
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NAME: Michael S. Hughes |
POSITION TITLE: Assistant Research Professor of Medicine |
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EDUCATION/TRAINING (Begin
with baccalaureate or other initial professional education, such as nursing,
and include postdoctoral training.) |
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INSTITUTION AND LOCATION |
DEGREE (if applicable) |
YEAR(s) |
FIELD OF STUDY |
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B.A. |
1980 |
Physics/Mathematics |
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M.S. |
1982 |
Physics |
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Ph.D. |
1987 |
Physics |
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NOTE: The Biographical
Sketch may not exceed four pages. Items A and B (together) may not exceed two
of the four-page limit. Follow the
formats and instructions on the attached sample.
A.
Positions and Honors.
1988-1991: Associate Research Physicist; Center for Nondestructive
Evaluation,
1991-1992: Research Physicist; Center for Nondestructive Evaluation,
1992-1994: Senior Research Physicist; Mallinckrodt Inc.,
1994-2000: Research Associate; Mallinckrodt Inc.,
2000-present: Research Associate Professor Of Medicine
NASA Graduate Research Fellow, 1985-1988
B.
Selected peer-reviewed publications (in chronological order).
1. M.S. Hughes, "A Comparison of Entropy vs. Total Energy
Analysis of Ultrasonic Waves in Plexiglas with Flaws," J. Acoust. Soc.
Amer. 91(4),Pt. 1, April 1992, pp. 2272-2275.
2. M.S. Hughes, "Analysis of Ultrasonic Waveforms Using Shannon
Entropy," IEEE Ultrasonics Symposium, Vol. 92CH3118-7, pp. 1205-1209,
1992.
3. M.S. Hughes, "Analysis of Digitized Waveforms Using Shannon
Entropy," J. Acoust. Soc. Am., 91(4), February 1993, pp. 892-906.
4. M.S. Hughes, "Analysis of digitized waveforms using
5. M.S. Hughes, "NDE Imaging of Flaws Using Rapid Computation of
Shannon Entropy," IEEE Ultrasonics Symposium, Vol. 93CH3301-9, pp.
697-700, 1993.
6. C.S. Hall, J.N. Marsh, M.S. Hughes, J. Mobley, K.D. Wallace,
J.G. Miller, and G.H. Brandenburger, “Broadband Measurement of the Backscatter
Coefficient for Suspensions: A Potential Calibration Tool,” J. Acoust. Soc. Am., 101, pp. 1162-1171,
1997.
7. N. Marsh, C.S. Hall, M.S. Hughes, J. Mobley, J.G. Miller,
and G.H. Brandenburger, “Broadband Through-Transmission Signal Loss
Measurements of Albunex Suspensions at Concentrations Approaching In Vivo
Doses,” J. Acoust. Soc. Am., 101, pp.
1155-1161, 1977.
8. A.L. Klibanov, M.S. Hughes, J.N. Marsh, C.S. Hall,
J.G. Miller, J.H. Wible G.H. Brandenburger “Targeting Of Ultrasound Contrast
Material: An In Vitro Feasibility Study,” Acta
Radiologica, 38, Supplement 412, pp. 113-120, 1997.
9. J. Mobley, J. N. Marsh, C. S.
Hall, M.S. Hughes, G. H.
Brandenburger, James G. Miller, "Broadband measurements of phase velocity
in Albunex suspensions," J. Acoust.
Soc. Am., 103(4), April 1998, pp.2145-2153.
10. J.N. Marsh, M.S. Hughes, C.S. Hall, S.H. Lewis,
R.L. Trousil, G.H. Brandenburger, H. Levene, J.G. Miller, "Frequency and
concentration dependence of backscatter coefficient of the ultrasound contrast
agent Albunex," J. Acoust. Soc. Am.,
104(3), September 1998, pp.1654-1666.
11. A.L. Klibanov, K.W. Ferrara, M.S. Hughes, J.H. Wible, J.K. Wojdyla,
P.A. Dayton, K.E. Morgan, and G.H. Brandenburger, “Direct Video-Microscopic
Observation of the Dynamic Effects of Medical Ultrasound on Ultrasound Contrast
Microspheres,” Investigative Radiology,
33(12), 1998, pp. 863-869.
12. A.L. Klibanov, M.S. Hughes, J.K. Wojdyla, J.N. Marsh,
C.S. Hall, J.G. Miller, J.H. Wible, and G.H. Brandenburger, "Targeting of
ultrasound contrast material: Selective imaging of microbubbles in vitro,"
Academic Radiology, 5, S243-S246
(1998).
13. J. Mobley, K.R. Waters, C.S. Hall, J.N. Marsh, M.S. Hughes, G.H. Brandenburger, J.G. Miller, "Measurements
and predictions of the phase velocity and attenuation coefficient in
suspensions of elastic microspheres," J.
Acoust. Soc. Am., 106(2), 1999, pp. 652-659.
14. K.R. Waters, M.S. Hughes,
J. Mobley, G.H. Brandenburger, J.G. Miller," On the applicability of
Kramers-Krönig relations for ultrasonic attenuation obeying a frequency power
law," Accepted by JASA.
15. M.S. Hughes, J.N. Marsh,
A.L. Klibanov, G.H. Brandenburger, J.G. Miller, "A Device for Measurement
of Attenuation Coefficient and Phase Velocity of Nearly Pure Ultrasonic
Contrast Agents," IEEE Ultrasonics
Symposium, 1999.
16. J.N. Marsh, M.S. Hughes,
G.H Brandenburger, J.G. Miller, "Broadband Measurement of the
Scattering-to-Attenuation Ratio for Albunex at 37°C," Journal of Ultrasound in Medicine, 25 (8), pp. 1321-1324, 1999.
17. J.H. Wible, J.K. Wojdyla, M.S.
Hughes, G.H. Brandenburger, “Effects of Transducer Frequency and Output
Power on the Ultrasonographic Contrast Produced by Optison Using Fundamental
and Harmonic Imaging Techniques,” J.
Ultrasound in Medicine, 18, pp. 753-762, 1999.
18. A.L. Klibanov, M.S. Hughes,
F.S. Villanueva, R.J. Jankowski, W.R. Wagner, J.K. Wojdyla, J.H. Wible, G.H.
Brandenburger, “Targeting and ultrasound imaging of microbubble-based contrast
agents,” MAGMA Magnetic Resonance
Materials in Physics, Biology and Medicine, 8, pp. 177-184, 1999.
19. K.R. Waters, M.S. Hughes,
G.H. Brandenburger, J.G. Miller, “Kramers-Krönig Dispersion Relations for
Ultrasonic Attenuation Obeying a Frequency Power Law,” IEEE Ultrasonics Symposium, Vol. 99, 1999.
20. J.H. Wible, J.K.
Wojdyla, M.S. Hughes, and G.H.
Brandenburger, "Effects of transducer frequency and output power on the
ultrasonographic contrast produced by Optison using fundamental and harmonic
imaging techniques," Journal of Ultrasound in Medicine, 18(11), 753-762 (1999).
21. M.S. Hughes, A.L.
Klibanov, J.N. Marsh, J.G. Miller, “Broadband time-domain reflectometry
measurement of attenuation and phase velocity in highly attenuating suspensions
with application to the ultrasound contrast medium Albunex ®,” Journal of the Acoustical Socieyt of America,
108 (2), pp. 813-820, 2000.
22. K.R. Waters, M.S. Hughes,
J. Mobley, G.H. Brandenburger, J.G. Miller, “On the applicability of
Kramers-Kronig relations for ultrasonic attenuation obeying a frequency power
law,” Journal of the Acoustical Society
of America, 108 (2), pp. 556-563, 2000.
23. K.R. Waters, M.S. Hughes,
G.H. Brandenburger, J.G. Miller, “On a time-domain representation of the
Kramers-Kronig dispersion relations,” Journal
of the Acoustical Society of America, 108 (5), pp 2114-2119, Part I, 2000.
24.A.L. Klibanov, M.S. Hughes,
J.N. Marsh, C.S. Hall, J.G. Miller, G.H. Brandenburger, “Targeting Of
Ultrasound Contrast Material: Selective Imaging Of Microbubbles In Vitro,”
Presented at the 1997 CMR in Japan.
25. A.L. Klibanov, M.S. Hughes,
J.N. Marsh, C.S. Hall, J.G. Miller, G.H. Brandenburger, “Targeting of
Microbubbles: Selective In Vitro Binding to Solid Surfaces and Scattering of
Ultrasound”, presented at the 1997 UCMRR meeting in San Diego.
26. J.N. Marsh, C.S. Hall, M.S.
Hughes, J. Mobley, G.H. Brandenburger, J.G. Miller, “Broadband In Vitro
Measurements, and Velocity and Material Properties of Albunex,” presented at
the 1997 UCMRR meeting in
27. A.L. Klibanov, M.S. Hughes, J.K. Wojdyla, J.H. Wible,
and G.H. Brandenburger, "Destruction of contrast agent microbubbles in the
ultrasound field: The fate of the microbubble shell and the importance of the
bubble gas content," Academic Radiology, 9, S41-S45 (2002).
28. A.L. Klibanov, P.T.
Rasche, M.S. Hughes, J.K. Wojdyla,
K.P. Galen, J.H. Wible, and G.H. Brandenburger, "Detection of individual
microbubbles of an ultrasound contrast agent: Fundamental and pulse inversion
imaging," Academic Radiology, 9,
S279-S281 (2002).
29. J.H. Wible, K.P. Galen,
J.K. Wojdyla, M.S. Hughes, A.L.
Klibanov, and G.H. Brandenburger, "Microbubbles induce renal hemorrhage
when exposed to diagnostic ultrasound in anesthetized rats," Ultrasound in
Medicine and Biology, 28(11-12),
1535-1546 (2002).
30. A.L. Klibanov, P.T.
Rasche, M.S. Hughes, J.K. Wojdyla,
K.P. Galen, J.H. Wible, and G.H. Brandenburger, "Detection of individual
microbubbles of ultrasound contrast agents - Imaging of free-floating and
targeted bubbles," Investigative Radiology, 39(3), 187-195 (2004).
31. M.S. Hughes, J. N. Marsh, C.S. Hall, R.W. Fuhrhop, E.K. Lacy, G.M.
Lanza, S.A. Wickline, “Acoustic Characterization in Whole Blood and Plasma of
Site-Targeted Nanoparticle Ultrasound Contrast Agent for Molecular Imaging,” Journal of the Acoustical Society of America,
117 (2), pp 964-972.
32. Hughes, M.S., et al., Characterization
of Digital Waveforms Using Thermodynamic Analogs: Applications to Detection of
Materials Defects. I.E.E.E Transactions on Ultrasonics, Ferroelectrics, and
Frequency Control, 2005.
C. Research Support.
Hughes M.S.
ONGOING
RO1 HL42950-15 Wickline (PI) 08/01/95-07/31/06
National Heart, Lung, and Blood
Institute
Ultrasonic Tissue
Characterization of Cardiac Remodeling.
The major goals of
quantitative ultrasonic tissue characterization of cardiac remodeling are: 1)
to elucidate architectural alterations in myocardium that result from
cardiomyopathy, infarction, and hypertension, 2) to delineate improvement in
tissue remodeling after therapy with ACE inhibitors, and 3) to mathematically
model the physical determinants of ultrasonic scattering from myocardium and
predict mechanical properties of myocardial tissue.
Role: Co-Investigator
R01 HL59865-04 (Hughes) 12/19/97-6/30/06
NIH/NHLBI
Specific Tissue Targeted
Ultrasonic Contrast Agent.
The proposal aims to: 1)
characterize nanoparticle binding and contrast enhancement effects for
ultrasound imaging; 2) characterize clinically important features of
atherosclerosis with targeted ultrasound molecular imaging; and 3) optimize
nanoparticle formulation for clinical testing. The clinical impact of this
technology is expected to encompass early noninvasive detection of pathologies
such as atherosclerosis, convenient longitudinal outpatient evaluation, and
site-targeted delivery of therapeutics as clinically indicated.
Role: PI
Grant-In-Aid 0355474Z (Hughes)
American Heart
Association-Heartland Affiliate
Cardiac imaging via
information-theoretic signal receivers of backscatter from targeted
nanoparticle emulsions.
The goal of this project is to twofold.
The first goal is to delineate the bounds of linear behavior of liquid
perfluorocarbon nanoparticles as acoustic scatterers by establishing
quantitative threshold levels for incident acoustic pressure at which
nonlinearities in attenuation become evident, and to determine the ambient
temperature, acoustic power, concentration, and waveform shape required to
phase-convert at least one perfluorocarbon nanoparticle into a gas microbubble
in order to establish upper bounds on conditions required to convert
perfluorooctyl bromide (PFOB) nanoparticles to gas microbubbles and evaluate
relevance to in vivo conditions, if
any. The second objective is to investigate thermodynamic signal processing to
assess sensitivity improvements achieved by these receivers when used in
conjunction with targeted nanoparticle emulsions, by investigating, in vitro,
backscatter from suspensions of targeted emulsion maintained in a mixed state while
suspended in either saline or blood and to measure, in vitro, backscatter from
a thin layer of targeted emulsion adhering to thin layers of cardiac
tissue. A quantitative comparison of
conventional (b-mode integrated backscatter) and thermodynamic techniques will
be performed.
Role: PI
N01-CO-37007 Lanza (PI) 09/30/03-09/29/06
National Cancer Institute
Molecular Imaging and Therapy of
Solid Tumors with a Novel anb3-Directed
Nanoparticle
Targeted to the Neovasculature.
The ultimate aims of
this contract are to demonstrate the feasibility of this unique, targeted
diagnostic and therapeutic technology to detect angiogenesis associated with
solid tumors and to deliver local therapy.
Role: Co-Investigator